InterSketch: An Interleaved Reasoning Model with Self-correcting Visual Sketch and Stepwise Reward

While vision-language models (VLMs) have exhibited multi-turn visual reasoning capabilities, their reasoning trajectories remain relatively shallow and are dominated by a text-centric paradigm, limiting their applicability to complex visual challenges. In contrast, human-like thought typically involves long-horizon reasoning with an interleaved visual-textual chain-of-thought (VT-CoT). To bridge this gap, we introduce InterSketch, an interleaved reasoning model to enhance the VT-CoT capability via self-correcting and stepwise reward mechanisms. InterSketch dynamically generates intermediate visual sketches using external tools and interleaves them with textual reasoning, enabling effective perception and logical reasoning over long-horizon visual understanding tasks. Specifically, in the first cold-start stage, we propose a synthesized high-quality interleaved VT-CoT dataset and include a reflection mechanism to enable the model's capability in multi-turn interleaved reasoning and self-correction. In the subsequent reinforcement learning (RL) stage, we design a stepwise reward mechanism to mitigate the sparsity of reward signals inherent in end-only supervision over long-horizon reasoning. Extensive experiments on visual reasoning benchmarks demonstrate the effectiveness of InterSketch, even outperforming proprietary models such as Gemini-3-Pro.

Quantitative coronary calcification analysis for prediction of myocardial ischemia using non-contrast CT calcium scoring

Non-contrast computed tomography calcium scoring (CTCS) is widely recognized as an effective tool for cardiovascular risk stratification. This study aimed to develop a novel machine learning framework for predicting myocardial ischemia from routine non-contrast CTCS scans using quantitative coronary calcium assessment. This study analyzed 1,375 patients who underwent both non-contrast CTCS and regadenoson stress cardiac positron emission tomography myocardial perfusion imaging within one year at University Hospitals Cleveland Medical Center. A total of 74 variables, including clinical variables, Agatston score, and calcium-omics features, were evaluated. Relevant features were identified using XGBoost with Shapley Additive exPlanations (SHAP). Predictive models were trained and evaluated using 5-fold cross-validation. Among 987 patients, 89 (9%) were positive for myocardial ischemia. The final model incorporated the Agatston score, eight calcium-omics features, and age. The proposed model achieved a precision of 98.9+/-3.0%, sensitivity of 79.2+/-8.4, and F1 score of 87.7+/-5.3%. The addition of calcium-omics features significantly improved predictive performance compared with models using clinical variables alone or clinical variables with the Agatston score (p<0.05). Interestingly, the number of calcified arteries, despite being the lowest-ranked feature based on SHAP analysis, showed the strongest association with myocardial ischemia in logistic regression analysis (odds ratio: 3.63, 95% confidence interval: 2.80-4.77, p<0.00001). We developed a machine learning approach for predicting myocardial ischemia using routinely acquired non-contrast CTCS scans. Calcium-omics features provided incremental predictive value beyond conventional risk factors and Agatston scoring and may support more accessible cardiovascular risk stratification.

Machine learning prediction of obstructive coronary artery disease using opportunistic coronary calcium and epicardial fat assessments from CT calcium scoring scans

Non-contrast computed tomography calcium scoring (CTCS) is a cost-effective imaging modality widely used to detect coronary artery calcifications. This study aimed to develop an advanced machine learning framework that utilizes quantitative analyses of coronary calcium and epicardial fat from CTCS images to predict obstructive coronary artery disease (CAD). The study population consisted of 1,324 patients from the SCOT-HEART clinical trial who underwent both CTCS and coronary CT angiography. We extracted and analyzed a broad range of features, including 24 clinical variables, 189 calcium-omics, and 211 epicardial fat-omics features from the CTCS images. Feature selection was conducted using the CatBoost algorithm combined with SHapley Additive exPlanation (SHAP) values. Predictive modeling utilized the CatBoost gradient boosting method, focusing on the most informative features. From an initial set of 424 candidate features, 14 were identified as most predictive through the CatBoost-SHAP method. The top two predictive features originated from fat-omics, with the remaining 12 features derived from calcium-omics. The optimized model achieved robust predictive capabilities, demonstrating a sensitivity of 83.1+/-4.6%, specificity of 93.8+/-1.7%, accuracy of 85.3+/-2.0%, and an F1 score of 73.9+/-3.3%. Inclusion of calcium-omics and fat-omics data significantly improved predictive performance. Notably, the model also showed reliable predictive accuracy in patients with diverse coronary calcium scores, including cases with obstructive CAD despite a zero-calcium score. This innovative approach holds promise for improving clinical decision-making and potentially reducing dependence on contrast-enhanced or invasive diagnostic procedures, particularly within low-to intermediate-risk patient groups.

SDM: A Powerful Tool for Evaluating Model Robustness

Gradient-based attacks are important methods for evaluating model robustness. However, since the proposal of APGD, it has been difficult for such methods to achieve significant breakthroughs. To achieve such an effect, we first analyze the issue of "high-loss non-adversarial examples" that degrades attack performance in previous methods, and prove that this issue arises from inappropriate objectives for adversarial example generation. Subsequently, we reconstruct the objective as "maximizing the difference between the non-ground-truth label probability upper bound and the ground-truth label probability", and proposes a novel and powerful gradient-based attack method named Sequential Difference Maximization (SDM). SDM establishes a three-layer optimization framework of "cycle-stage-step". It adopts the negative probability loss function and the Directional Probability Difference Ratio (DPDR) loss function in the initial and subsequent optimization stages, respectively, and approaches the ideal objective of adversarial example generation via stage-wise sequential optimization. Experiments demonstrate that compared with previous state-of-the-art methods, SDM not only achieves stronger attack performance but also exhibits superior cost-effectiveness. The code is available at https://github.com/X-L-Liu/ICML-SDM.

Dynamic Cross-Modal Prompt Generation for Multimodal Continual Instruction Tuning

Multimodal Large Language Models (MLLMs) achieve strong performance through instruction tuning, yet real-world deployment often requires continual capability expansion across sequential tasks. In such scenarios, Multimodal Continual Instruction Tuning (MCIT) aims to acquire new capabilities while limiting catastrophic forgetting. Existing methods mainly follow a module-composition paradigm: they maintain task-level prompts or LoRA experts and dynamically route or aggregate a subset of them at inference. However, samples within the same task can still differ substantially in visual scenes, question intents, and reasoning demands. This motivates instance-level adaptation to individual query-image pairs rather than only selecting or combining task-level modules. To this end, we propose DRAPE (Dynamic Cross-Modal Prompt Generation), a prompt-learning framework that synthesizes continuous instance-specific soft prompts for MCIT. Instead of selecting prompts from a fixed pool, DRAPE derives prompt queries from the textual instruction and cross-attends to visual patch features, producing query-image conditioned prompts that are prepended to the frozen LLM. To mitigate forgetting during sequential updates, DRAPE applies null-space gradient projection to the shared projector and uses CLIP-based prototype routing for task-label-free generator selection at inference. Extensive experiments on MCIT benchmarks show that DRAPE achieves state-of-the-art performance among representative prompt-based and LoRA-based continual-learning baselines.

Pest-Thinker: Learning to Think and Reason like Entomologists via Reinforcement Learning

Pest-induced crop losses pose a major threat to global food security and sustainable agricultural development. While recent advances in Multimodal Large Language Models (MLLMs) have shown strong potential for visual understanding and smart agriculture, their direct application to pest recognition remains limited due to the domain's unique challenges such as high inter-species complexity, intra-species variability, and the scarcity of expert-annotated data. In this work, we introduce Pest-Thinker, a knowledge-driven reinforcement learning (RL) framework that enables MLLMs to reason over fine-grained pest morphology. We first construct two high-definition pest benchmarks, QFSD and AgriInsect, comprising diverse species and expert-annotated morphological traits. Leveraging these datasets, we synthesize Chain-of-Thought (CoT) reasoning trajectories to facilitate structured learning of pest-specific visual cues through Supervised Fine-Tuning (SFT). Subsequently, we employ Group Relative Policy Optimization (GRPO) with a novel feature reward that guides the model to focus on observable morphological evidence, assessed by an LLM-as-a-Judge strategy. Extensive experiments demonstrate that Pest-Thinker substantially improves both in-domain and out-of-domain morphological understanding, marking a step toward expert-level visual reasoning for intelligent agricultural pest analysis. The datasets and source code are available upon acceptance.

HumANDiff: Articulated Noise Diffusion for Motion-Consistent Human Video Generation

Despite tremendous recent progress in human video generation, generative video diffusion models still struggle to capture the dynamics and physics of human motions faithfully. In this paper, we propose a new framework for human video generation, HumANDiff, which enhances the human motion control with three key designs: 1) Articulated motion-consistent noise sampling that correlates the spatiotemporal distribution of latent noise and replaces the unstructured random Gaussian noise with 3D articulated noise sampled on the dense surface manifold of a statistical human body template. It inherits body topology priors for spatially and temporally consistent noise sampling. 2) Joint appearance-motion learning that enhances the standard training objective of video diffusion models by jointly predicting pixel appearances and corresponding physical motions from the articulated noises. It enables high-fidelity human video synthesis, e.g., capturing motion-dependent clothing wrinkles. 3) Geometric motion consistency learning that enforces physical motion consistency across frames via a novel geometric motion consistency loss defined in the articulated noise space. HumANDiff enables scalable controllable human video generation by fine-tuning video diffusion models with articulated noise sampling. Consequently, our method is agnostic to diffusion model design, and requires no modifications to the model architecture. During inference, HumANDiff enables image-to-video generation within a single framework, achieving intrinsic motion control without requiring additional motion modules. Extensive experiments demonstrate that our method achieves state-of-the-art performance in rendering motion-consistent, high-fidelity humans with diverse clothing styles. Project page: https://taohuumd.github.io/projects/HumANDiff/

Universal and efficient graph neural networks with dynamic attention for machine learning interatomic potentials

The core of molecular dynamics simulation fundamentally lies in the interatomic potential. Traditional empirical potentials lack accuracy, while first-principles methods are computationally prohibitive. Machine learning interatomic potentials (MLIPs) promise near-quantum accuracy at linear cost, but existing models still face challenges in efficiency and stability. We presents Machine Learning Advances Neural Network (MLANet), an efficient and robust graph neural network framework. MLANet introduces a dual-path dynamic attention mechanism for geometry-aware message passing and a multi-perspective pooling strategy to construct comprehensive system representations. This design enables highly accurate modeling of atomic environments while achieving exceptional computational efficiency, making high-fidelity simulations more accessible. Tested across a wide range of datasets spanning diverse systems, including organic molecules (e.g., QM7, MD17), periodic inorganic materials (e.g., Li-containing crystals), two-dimensional materials (e.g., bilayer graphene, black phosphorus), surface catalytic reactions (e.g., formate decomposition), and charged systems, MLANet maintains competitive prediction accuracy while its computational cost is markedly lower than mainstream equivariant models, and it enables stable long-time molecular dynamics simulations. MLANet provides an efficient and practical tool for large-scale, high-accuracy atomic simulations.

Sharper Generalization Bounds for Transformer

This paper studies generalization error bounds for Transformer models. Based on the offset Rademacher complexity, we derive sharper generalization bounds for different Transformer architectures, including single-layer single-head, single-layer multi-head, and multi-layer Transformers. We first express the excess risk of Transformers in terms of the offset Rademacher complexity. By exploiting its connection with the empirical covering numbers of the corresponding hypothesis spaces, we obtain excess risk bounds that achieve optimal convergence rates up to constant factors. We then derive refined excess risk bounds by upper bounding the covering numbers of Transformer hypothesis spaces using matrix ranks and matrix norms, leading to precise, architecture-dependent generalization bounds. Finally, we relax the boundedness assumption on feature mappings and extend our theoretical results to settings with unbounded (sub-Gaussian) features and heavy-tailed distributions.

Human Video Generation from a Single Image with 3D Pose and View Control

Recent diffusion methods have made significant progress in generating videos from single images due to their powerful visual generation capabilities. However, challenges persist in image-to-video synthesis, particularly in human video generation, where inferring view-consistent, motion-dependent clothing wrinkles from a single image remains a formidable problem. In this paper, we present Human Video Generation in 4D (HVG), a latent video diffusion model capable of generating high-quality, multi-view, spatiotemporally coherent human videos from a single image with 3D pose and view control. HVG achieves this through three key designs: (i) Articulated Pose Modulation, which captures the anatomical relationships of 3D joints via a novel dual-dimensional bone map and resolves self-occlusions across views by introducing 3D information; (ii) View and Temporal Alignment, which ensures multi-view consistency and alignment between a reference image and pose sequences for frame-to-frame stability; and (iii) Progressive Spatio-Temporal Sampling with temporal alignment to maintain smooth transitions in long multi-view animations. Extensive experiments on image-to-video tasks demonstrate that HVG outperforms existing methods in generating high-quality 4D human videos from diverse human images and pose inputs.